Posted by alesta on August 21, 2004, at 17:32:26
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI--DAVE, posted by Dave001 on August 20, 2004, at 18:25:25
Hi, dave, :)
good to hear from you! Excellent job! There is so much quality information in your post that I still need to sort through. I was looking for which medications they were using in the study, but didn’t see them; guess I didn’t look hard enough.:) I checked on mirapex and it didn’t look that great from a side-effect point-of-view (e.g. hair loss!) lexapro, I don’t know too much about. I’m definitely going to check on that.
Question: you said you wanted to quit Dexedrine due to neurotoxicity. Do you feel that all stimulants are neurotoxic? I ask because I am considering augmenting prozac with low-dose Ritalin for dopamine and to combat the ssri-related fatigue.
Thank you again for your wealth of pertinent information. You’re really helpful.:)
Take care,
Amy :)> > thank you, dave. mirapex, huh? i'll have to look into that.
> >
>
> Keep in mind that that is only one of the many options though. Have you ever tried Amantadine? Selegeline can also be used with SSRIs if the dose isn't too high (I think <= 10 mg/day). There has been at least one study on the safety of combining selegeline with an SSRI. I do share the same basic mentality with you in that I feel that SSRI monotherapy is a prescription for failure (ugh, not to get anyone discouraged though! :-) in most cases because of the effects inherent with raising serotonin, such as reduced dopamine activity and elevations in prolactin, even if subclinical. I've also seen decreased expression of nitric oxide synthase in most of the SSRI studies, including Effexor; the one exception I've found has been citalaprom/escitalaprom (Celexa/Lexapro). Incidentally, it seems that Lexapro and Mirapex are going to be used in that clinical study posted earlier in this thread.
>
> See the URL:
> http://clinicalstudies.info.nih.gov/detail/A_2004-M-0227.html
>
> If you scroll down toward the bottom of the page, you'll see both "Pramipexole" and "Escitalopran" (sic) listed as "Keywords."
> > my god, you took all that stuff at the same time, and it still didn't work? talk about drug-resistant! (FYI i'm one of those people that gets drunk off one beer <g>. that combo would probably do me in.)
> >
>
> Yeah, well it did have some effect; it's just that the positives didn't outweigh the negatives. I was on the Dexedrine for a long time before starting the Parnate, though, so it had already lost much of its effectiveness. I started Dexedrine when I was about 17/18 for "ADD", but I really want to stop due to concerns of neurotoxicity. The problem is finding an opportune moment where I can just say, "OK, now seems like a good time to begin months of amphetamine withdrawal."
>
> > Good luck to you, too! keep me posted with whatever you try. :)
> >
> Thanks, you too!
>
> Dave
>
poster:alesta
thread:378302
URL: http://www.dr-bob.org/babble/20040821/msgs/380503.html