Posted by Larry Hoover on August 17, 2004, at 11:13:06
In reply to Strong anti-dep. with no cardio effects with adder, posted by Fromage47 on August 17, 2004, at 10:50:20
> I am in great need of a very strong anti-depressant (I have been on them all - currently i am on imipramine) - i like the imipramine's effects as an anti-depressant, but it is giving me severe cardiovascular issues in combination with the adderall I take. It is raising my blood pressure and causing a panic disorder that i conquered years ago. I have to quit taking it, but i dont want to quit the adderall. Any suggestions?
Lofepramine?
Drugs. 1989 Feb;37(2):123-40.
Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
Lancaster SG, Gonzalez JP.
ADIS Drug Information Services, Manchester, England.
Lofepramine is a tricyclic antidepressant that is structurally similar to imipramine and is extensively metabolised to desipramine. In the absence of other major pharmacological effects it appears that its antidepressant activity stems from the facilitation of noradrenergic neurotransmission by uptake inhibition, and possibly by the additional facilitation of serotoninergic neurotransmission. The overall therapeutic efficacy of lofepramine is comparable to that of imipramine, amitriptyline, clomipramine, maprotiline and mianserin in patients with depression of varying severity, and coexisting anxiety. Dry mouth is the most commonly reported side effect of usual therapeutic doses of lofepramine, but the incidence of this and other anticholinergic side effects is less among patients treated with lofepramine than with imipramine. Lofepramine has not been associated with adverse effects on cardiac function even in cases of attempted suicide by overdose. Thus, providing its apparent favourable side effect profile is confirmed in practice, lofepramine may be a valuable alternative for treatment of the depressed patient where a tricyclic is indicated.
poster:Larry Hoover
thread:378652
URL: http://www.dr-bob.org/babble/20040817/msgs/378661.html