Posted by SDA on August 12, 2004, at 19:35:09
In reply to Re: Zoloft makes OCD worse?, posted by linkadge on August 12, 2004, at 15:22:31
> Serotonin antagonists can make OCD worse, but zoloft is not a serotonin antagonist, it is a serotonin agonist. I found that SSRIs helped some aspects of OCD and made others worse. They seemed to stop the need to repeat things just for the sake of repeating them, but they also made my mind kind of always active, and harder to let my mind just stop for a while.
>
> LinkadgeThanks for that clarification. I've always thought of SSRIs as antagonists since they block things rather than stimulate.
Here's what I understand now: SSRIs act as agonists by indirectly facilitating more stimulation of serotonin receptors on the other end of the synapse. An antagonist would either block those receptors or decrease the amount of active serotonin.
Is that correct? I do remember reading an article that specifically mentioned SSRIs making OCD worse before better, though.
poster:SDA
thread:376913
URL: http://www.dr-bob.org/babble/20040811/msgs/376999.html