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Re: TSH Levels and Thyroid Meds? BarbaraCat

Posted by Cairo on July 25, 2004, at 21:35:55

In reply to Re: TSH Levels and Thyroid Meds? Cairo, posted by BarbaraCat on July 25, 2004, at 14:01:41

> My personal feeling is that it's a faulty mixture primarily of a circadian disorder that results in disordered sleep phases. This may be the result of damaged hypthalamus and hippocampal structures, the damage caused by too much stress hormone (proably glutamate). Whatever stories or reasons we got there, we struggle from the outcome of dysfunctional brain and hormonal systems that ain't working right. I don't know how Substance P plays into this except it's a confirmation of the hypersensitive condition. I'm convinced our alarm systems, our amygdalas, are hardwired for alarm and hypervigilance. This can make you very tired. All the hormones get out of whack. The pituitary loses its ability to direct the show. That's why Dr. John Lowe talks about thyroid being the culprit. It is only one of many and he has to look farther upstream for the source.
- BarbaraCat


Sleep disorder in FMS is probably due to HPA axis dysfunction:

http://www.endotext.org/adrenal/adrenal31/adrenalframe31.htm

Inhibition of substance P may help as an adjunct for pain in some cases. It's too bad that
aprepitant was not approved for depression, as that would probably have lowered the price since it would have been used chronically and they couldn't justify charging $80 per tablet as they do for Emend (approved for chemotherapy induced nausea).

As I get some relief from Neurontin, though I need drug holidays from it, I'll be eager to try Pregabalin which I understand will be available later this year.

Meanwhile, I'm using our heated pool every day and it helps with stiffness. My recent MRI just came back with disc bulging at C4-5, so I'll need to take care of that as it's feeding the pain cycle. But I surmise that HPA axis dysfunction has contributed to that also via inflammation and mechanically.

Cairo


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