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Re: Is Trimipramine ever used? 1980Monroe

Posted by Larry Hoover on July 20, 2004, at 9:32:33

In reply to Re: Is Trimipramine ever used?, posted by 1980Monroe on July 20, 2004, at 9:19:54

> It's mentioned the most in an "ineffective" antidepressant throught most of these posts.

It may be a poor antidepressant (like e.g. trazodone), but it is an excellent hypnotic.

I'm using low-dose (25 mg) trimipramine as a sleep aid.

Recent work on insomnia has pointed to the H1 histamine receptor as the key to the induction of sleep. Remeron has relatively high H1 binding, but three tricyclics are better yet. In declining order, they are doxepin, trimipramine, amitryptiline. As far as I know, there is no drug with higher H1 binding affinity than doxepin, at least within the antidepressant category.





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