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What max dose of PARNATE before giving up? King Vultan

Posted by don_bristol on July 17, 2004, at 4:50:40

In reply to Re: King Vultan-MAOI Diet?, posted by King Vultan on July 14, 2004, at 14:22:44

King Vultan wrote:

> >
> >
> > "This article is one of the two best I have seen for
> > information on MAOIs".
> >
> Here is the other one:


Hi King Vultan (Todd)

Thank you for the link. You see quite clues-up on these things - do you mind if I ask you to say very briefly what MAOIs you have tried.

I am on Parnate (tranylcypromine) but my psychiatrist is very cautious. After a few months on 20 mg with little effect I had to ask to go from 20 to 30 mg and then she was wary of doing that.

So I am interested in the Cole and Bodkin article where they refer to dosage. They say

--- QUOTE ---
A rule of thumb is to start with one MAOI pill the first day and increase the dosage by one pill every 4 to 7 days until these levels are reached:

1 mg/kg/d for phenelzine;
40 mg/d for tranylcypromine and isocarboxazid;
45 mg/d for selegiline.
---- END QUOTE ----

However their table 2 says this:

--- QUOTE ---
Isocarboxazid 20 to 80 mg/d
Phenelzine 30 to 90 mg/d
Selegiline 15 to 60 mg/d
Tranylcypromine 20 to 100 mg/d
--- END QUOTE ----

It is their upper limit of Parnate/tranylcypomine which I am interested in. It seems a long way from a rule of thumb value of 40mg to the upper limit of 100 mg.

Do you or anyone else here have any views on this?

I suppose my question is not really "what is the upper limit" but what dose of Parnate should I go to before I determine it is not working for me?




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