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Re: bromocriptine King Vultan

Posted by chemist on July 12, 2004, at 16:19:30

In reply to Re: bromocriptine Questionmark, posted by King Vultan on July 12, 2004, at 8:37:10

> > Does anyone have any experience with bromocriptine? i'm getting a prescription for it in a couple of days in my latest attempt to ease the anorgasmia caused by Nardil. (So far cyproheptadine, amantadine, methylphenidate, Adderall, and [from when i was on Paxil] Wellbutrin and Remeron were all failures). (Oh and Ginkgo helped minimally if at all).
> > So a lot is riding on this bromocriptine-- although i am pretty dubious, unfortunately. Anyway, any information you can pass to me about bromocriptine (and/or relief from Nardil anorgasmia) would be highly appreciated. Thanks.
> I've studied bromocriptine and some of the other dopamine agonists to some extent and was considering trying to badger my pdoc into prescribing one of them for me last year for my own lack of libido. Chemist is correct in that this drug seems to be mainly associated with treating hyperprolactinemia, but it can also be used for Parkinson's, and there is a considerable amount of anecdotal evidence that it may have efficacy as a sexual aid in increasing libido.
> As for anorgasmia, considering what you've already tried, I would not be that optimistic, but there is no real harm in trying it. Watch out for the nausea and somnolence that these dopamine agonists often generate. They are also noted for causing dizziness--I believe from orthostatic hypotension. Why the side effects of these drugs are so different from that of more conventional dopaminergic drugs such as the stimulants is something I find a bit mystifying.
> I did recently read about another treatment for anorgasmia using bethanecol (Urecholine) 10 to 30 minutes prior to sexual activity. Unfortunately, this appears to be some kind of cholinergic drug, as it has proved successful for treating orgasm problems in imipramine patients. Imipramine is notoriously anticholinergic, while Nardil is not, the orgasm problems with Nardil being likely caused by bombardment of 5-HT2A receptors by all that extra serotonin that is available. As such, I would not expect bethanecol to be very effective in treating your problem.
> Todd

hello all, chemist here...i have to throw in my two cents about bethanechol...i usually will not post to a query that overlaps with some research stuff i do that is covered by confidentiality/non-disclosure stuff - i studiously avoided the thread about AChE/ChE - but i have to say, this drug is pretty much good for two things, and two things only: increasing urinary frequency and voiding your bladder. i'm with the King in that the libido issues are a murky area and that these alternatives are likely to be ineffective. this one, in particular - even if it worked sexually - would keep you in the restroom, not the bedroom. all the best, chemist




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