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Re: someone tell me something about AMYTAL » 1980Monroe

Posted by chemist on July 9, 2004, at 14:07:08

In reply to Re: someone tell me something about AMYTAL, posted by 1980Monroe on July 9, 2004, at 12:12:25

> Was amobarbital ever used for anxiety in the past?
>
> I belive it was approved or released in 1932 but im not sure which.
>
> I know nembutral and seconal are mainly for insomnia, but not for anxiety because they are too strong.
>
> Can amytal be classifed as a antianxiety drug or just a hypnotic.
>
> Thanks chemist, your the best.

well, that's one vote :)....i'm not real up on this category, so i'll give you what i've cribbed from my merck index and manual first: therapeutic category is sedative/hypnotic, and u.s. patent on amobarbital was 1924. i did a google on barbiturate and found a couple of sites that i would characterize as being partisan, pro-drug sites but contain plenty of historical information that appears unbiased in terms of dates, but again, i'm not sure of the veracity, but dates probably don't matter. the page i'm looking at now indicates that barbiturates had been used for sleep and ``to calm the nerves'' before the US FDA bad guys lowered the boom in the late 1940's: www.druglibrary.org/schaffer/Library/studies/cu/cu30.html. since barbiturates have been around in usable form since around 1094 (give me +/- a couple of years), it seems reasonable that small doses would have been used as anxiolytics and larger doses for sedation/sleep. remember, the first benzo was synthesized in 1959, heroin was on the outs by the mid 1920s, and there were few other options to ``calm the nerves'' other than chloral hydrate and probably a few others i'm missing. so, in sum, i'm pretty sure the answer is ``yes'' that barbiturates have been used in the past for anxiety. i am also aware that the abuse potential is pretty high, and they are not on most doctors' lists of treatments for anxiety most likely for this reason, although just my take. i would imagine that a small dose of amobarbital would do the trick, you'd just have to watch the dose escalation/tolerance stuff......all the best, chemist


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