Posted by chemist on July 8, 2004, at 9:40:31
In reply to P450-CYP2D6, posted by Sad Panda on July 8, 2004, at 4:33:37
> Hi All,
>
> I am switching to Effexor + Nortriptyline & am wondering what my plasma levels of each drug will do since they both use the same enzyme. Should I reduce my Effexor doseage by 50%?
>
> Any & All help appreciated. :)
> Panda.
>
hey panda, just chiming in with my two-cents to say i agree with the other posters in re: inhibition of cyp4502d6 not being much of an issue...both drugs are strong substrates and relatively weak inhibitors of this isoenzyme....i would argue that venlafaxine is *slightly* more likely to have a smaller K_{i} for 2D6 than nortriptyline, as the tertiary amine is actually a quaternary amine in the salt and thus higher affinity for 2D6 than the (in salt) tertiary amine in nortriptylline....all the best as usual, chemist
poster:chemist
thread:363939
URL: http://www.dr-bob.org/babble/20040704/msgs/363993.html