Posted by anxiety_free on July 4, 2004, at 9:04:28
In reply to Tricyclics boost amphetamine?, posted by Philidor on July 3, 2004, at 14:53:48
> It appears to be no secret that they do:
>
> "Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause STRIKING AND SUSTAINED INCREASES in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated." (emphasis mine)
>
> SOURCE: http://www.ethex.com/pages/pdf/58177031204_PIS.pdf
>
> My question is, why has this fact not gotten greater attention and application in the treatment of ADHD and narcolepsy?
>
> Dr. Bob????Hi! In the past (and occasionally now, as well) tricyclics are used for ADHD/Narcolepsy...in ADHD sometimes a tricyclic can be used alone. But, tricyclics have more side effects than newer drugs , and since they're old there aren't many companies pushing them (except for the kinda new Tofranil...Tofranil PM). But I have ADHD and depression and my doc gave me a tricyclic (Tofranil PM) because it will boost my stimulant,which helps ADHD and depression. But most of the time when a doc opts for anti-depressant therapy for ADHD, they go for wellbutrin, sometimes adding other agents...and of course now there's straterra. Its too bad really..tricyclics are cheap, effective, and they have decades of research behind them.
poster:anxiety_free
thread:362828
URL: http://www.dr-bob.org/babble/20040704/msgs/362972.html