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Re: FDA Finds Gepirone ER 'Not Approvable'

Posted by SLS on June 26, 2004, at 6:09:39

In reply to Re: FDA Finds Gepirone ER 'Not Approvable', posted by SLS on June 25, 2004, at 22:20:32

I neglected to mention that buspirone and gepirone are both metabolized to form 1-PP (1-(2-pyrimidinyl)-piperazine). 1-PP is a NE alpha-2 receptor antagonist like Remeron, only without the potent antihistaminic properties of Remeron. This is yet another rationale for the use of these drugs as augmentors of antidepressants.


- Scott

 

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URL: http://www.dr-bob.org/babble/20040621/msgs/360593.html