Posted by zeugma on June 21, 2004, at 17:27:18
In reply to Provigil makes u sleepy...like strattera 4 some? » King Vultan, posted by psychosage on June 21, 2004, at 12:16:57
Reuptake is how neurotransmitter is conserved, so in theory a powerful reuptake inhibitor can deplete one of the transmitter in question. I have only heard of this happening, however, after massive overdoses of NRI's. I suspect the reason Strattera makes some sleepy (I would say fatigued) is because of some unknown property of the molecule, and not its norepinephrine reuptake inhibition.
On second thought, something else occurs to me: Strattera's rapid absorption in the CNS followed by its almost equally rapid exit (half-life under 5 hours). This can lead to sudden, tremendous fluctuations in NE levels, which could well put a lot of strain on the CNS and cause the fatigue/sleepiness reactions. Either or both of these theories could be true.
Provigil's mechanism, whatever it is, is not NE reuptake inhibition. It seems to act on hypocretins (recently discovered neuropeptides in the hypothalamus) and to some extent on dopamine, and maybe most of the other amines as well, but not through reuptake inhibition.
poster:zeugma
thread:358279
URL: http://www.dr-bob.org/babble/20040621/msgs/358727.html