Posted by Sad Panda on May 31, 2004, at 22:48:36
In reply to how can 22.5 of remeron be more sedating than 15mg, posted by ravenstorm on May 31, 2004, at 19:07:52
> I guess that is what I really want to know! Got a little carried away in the last post.
>
> Am I just getting more side effects (ie more histamine affect ect by bumping up but still being at a lower dose?)
>
> Do you have to go over 30mg to get less sedation?(ie hit the noradreg (can't spell it-so I'll stop half way through))
>
> Or am I just continuing in the med-freak tradition and having an opposite reaction to the drug then everybody else?
>
> Thanks!
>
> P.S. Still haven't decided if I should stay with the bumped up dose tonight. Have never had more side effects with a bump up than when starting a drug!!>
>
>Hi Ravenstorm,
Remeron is a Alpha-2 Adrenergic antagonist & this effect becomes stronger as you go higher. A-2 antagonism raises insulin levels which lowers blood sugar.
For me 15mg was the best amount for sleep, adding extra doesn't sedate deeper, but it does sedate longer. If I were you I would stay at 15mg & try an SSRI again. Remeron by itself is rarely a good AD, but it is a good sleep aid & it makes SRI's much more tolerable by block it's effects on 5-HT2 & 5-HT3
Cheers,
Panda.
poster:Sad Panda
thread:352416
URL: http://www.dr-bob.org/babble/20040527/msgs/352558.html