Posted by btnd on May 29, 2004, at 19:43:00
In reply to Nardil, SNRIs, tyramine, hypertension, posted by Michael Bell on May 29, 2004, at 13:51:37
> It's amazing to me that one of the best meds for SP is so hard to attain and stay on b/c of hypertensive risk. I'm not that knowledgeable about chemistry, but isn't there some kind of substance that someone can ingest to take over MAO's role of break down tyramine? Sort of like taking lactaid pills for people who can't break down lactic acid properly. Then someone on Nardil or Parnate can take that substance along with the MAOI to help prevent hypertensive crisis.
Does hypertensive crisis happen only when you eat certain foods? or does it happen all on their own?Did you experience other side-effects like anorgasmia during your Nardil treatment?
> Moreover, I remember reading a study which concluded that since SNRIs (Reboxetine, Strattera) inhibit norepinephrine release, taking it with MAOIs may lessen the risk of hypertensive crisis. Does anyone have knowledge or personal experience with this combo?
If they would release NE - they probably could be of help. But they are NE reuptake inhibitors -> meaning they make NE more available/more is transmitted. They are 'activating' kinda drugs. So my call on them would be that they wouldn't lower BP. However if you read a study on it - there might be some other action or I'm simply wrong ;-) It'd be great if you could post the study or find a link to it ;-)
poster:btnd
thread:351877
URL: http://www.dr-bob.org/babble/20040527/msgs/351959.html