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Re: Lofepramine

Posted by King Vultan on May 3, 2004, at 20:04:56

In reply to Lofepramine, posted by jms600 on May 3, 2004, at 15:59:27

> Anyone ever tried Lofepramine? My doctor said its not as good as the SSRIs - is this true?
>
> Was the Lofepramine activating/stimulating or was it sedating?
>
> I wan't to try a Tricyclic, and I've heard that Lofepramine has the weakest anticholinergic effects.


Lofepramine is what is called a prodrug or drug precursor. Its major metabolite is desipramine, which is the tricyclic that does have the fewest anticholinergic effects.

Todd


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