Posted by SLS on April 23, 2004, at 11:18:40
In reply to Re: Which AD's are most and least agitating, posted by King Vultan on April 23, 2004, at 8:00:58
> Nortriptyline was by far the least activating of any of the drugs I've tried.
I found it to be smooth as well, although it had a soporific effect on me when I first started it. Unfortunately, it doesn't appear that I have a therapeutic window for nortriptyline. 75mg was too little and 100mg was too much. The only times I felt improved were during the first 36 hours after a change in dosage, either up or down. There wasn't so much as a sliver of a dosage range at which the antidepressant effect would stabilize. This probably isn't so rare an event I imagine. For most people, the therapeutic window for nortriptyline lies with blood levels between 50-150 ng/ml. One of my doctors once told me that there is a tendency for an individual to respond to either desipramine or nortriptyline but not to both. I'm not sure how true this is.
- Scott
poster:SLS
thread:339005
URL: http://www.dr-bob.org/babble/20040423/msgs/339142.html