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Re: Which meds antagonize 5-HT3 receptors?

Posted by Vanillintabaktöne on April 21, 2004, at 22:29:58

In reply to Which meds antagonize 5-HT3 receptors?, posted by jerrympls on April 21, 2004, at 22:12:46

> I know many antipsychotics antagonize 5-HT2 receptors - but are there any "psychiatric" meds that also antagonize 5-HT3?
> Thanks in advance
> Jerry

Hello jerry,

Agonism or if you prefer, Stimulation of 5-HT 3 receptors induce nausea + vomiting. In oncology, agents such as ondansteron ([Zofran] there are a few others)are essentially 5-HT 3 receptor antagonists and are prescribed to alleviate chemotherapy induced nausea/vomiting and are efficacious in doing so.

Antiemetic efficacy results from a simultaneous action at peripheral and central 5-HT3-receptors. Other peripheral actions include reduction of secretion and diarrhea caused by increased intestinal serotonin content (e.g. in carcinoid syndrome), a limited antiarrhythmic activity and a reduction of experimentally induced pain. CNS effects comprise anxiolysis, attenuation of age-associated memory impairment, reduction of alcohol consumption in moderate alcohol abuse and an antipsychotic effect in patients with parkinson psychosis. In migraine, 5-HT3-receptor antagonists show moderate efficacy, as more @

Hope that offers some insight.




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