Posted by Vanillintabaktöne on April 21, 2004, at 22:29:58
In reply to Which meds antagonize 5-HT3 receptors?, posted by jerrympls on April 21, 2004, at 22:12:46
> I know many antipsychotics antagonize 5-HT2 receptors - but are there any "psychiatric" meds that also antagonize 5-HT3?
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> Thanks in advance
> Jerry
Hello jerry,Agonism or if you prefer, Stimulation of 5-HT 3 receptors induce nausea + vomiting. In oncology, agents such as ondansteron ([Zofran] there are a few others)are essentially 5-HT 3 receptor antagonists and are prescribed to alleviate chemotherapy induced nausea/vomiting and are efficacious in doing so.
Antiemetic efficacy results from a simultaneous action at peripheral and central 5-HT3-receptors. Other peripheral actions include reduction of secretion and diarrhea caused by increased intestinal serotonin content (e.g. in carcinoid syndrome), a limited antiarrhythmic activity and a reduction of experimentally induced pain. CNS effects comprise anxiolysis, attenuation of age-associated memory impairment, reduction of alcohol consumption in moderate alcohol abuse and an antipsychotic effect in patients with parkinson psychosis. In migraine, 5-HT3-receptor antagonists show moderate efficacy, as well..........read more @http://nootropics.com/5-ht3/
Hope that offers some insight.
poster:Vanillintabaktöne
thread:338580
URL: http://www.dr-bob.org/babble/20040417/msgs/338591.html