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Re: Nuts on Wellbutrin - help!

Posted by King Vultan on April 20, 2004, at 8:10:03

In reply to Nuts on Wellbutrin - help!, posted by starflower on April 20, 2004, at 1:00:50

Your story reminds me of one I read regarding a psychiatrist who took Wellbutrin and experienced all sorts of negative effects. It sounds as though it may not be the best choice for you. I had somewhat better luck on 300 mg/day (of the SR formulation, which is taken twice a day because it is faster releasing); however, I experienced extreme irritability after a few months on this dosage and was forced to discontinue it. Like you, I found 150 mg/day to not do a whole lot. This drug has a fairly narrow therapeutic index, as you need to get over a certain threshold to experience any therapeutic benefit, and this winds up being closer to the tolerance limit than is the case for some other drugs.

Seeing as though you have tried so many drugs, you might consider a 3rd line treatment of an MAOI. I also experienced emotional numbness on SSRIs but am finding none of that on Nardil, which seems to have a very natural method of action. If you don't want to go to that extreme, you might also want to consider a tricyclic antidepressant such as desipramine, protriptyline (Vivactil), or nortriptyline. I found these also to be very good in the emotional/spirituality department, in stark contrast to the way SSRIs have affected me.





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