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Re: As-needed AD use » linkadge

Posted by Questionmark on April 14, 2004, at 10:40:39

In reply to I disagree, posted by linkadge on April 13, 2004, at 18:22:02

> There is some research to suggest that sudden increase of serotonin can effect your mood.
>
> Why do large meals with loads of carbs make you feel better, because they acutely increase serotonin.
>
> As well it has been shown that tryptophan depleation very rapidly causes relapse back into depression. Especially if your mood problems seem to be cyclical or hormonally based.
>
> I know of a few people just need antidepressants to get them through their time of the month.
>
> People think that I am crazy but I felt emmediate antianxiety effects from taking SSRI's.
>
> Linkadge

i totally believe and understand that. i did as well. i felt about a few days of antianxiety and antidepressant effects when first starting, then about a week of deep depression, and then a gradual progression and then sustainance of antianxiety and, to some extent, antidepressant response. This all makes perfect sense when you look at the proposed serotonin receptor adaptations that occur after starting and staying on an SSRI: first, increased 5-HT in synapse due to 5-HT reuptake inhibition; then, decreased 5-HT in synapse due to continued activation of autoreceptors and the consequent inhibition of release; then finally, increased 5-HT levels in synapse again due to down-regulation of autoreceptors (and then eventually tolerance effects due to down-regulation of transporters and postsynaptic receptors, and inhibition of dopamine release [?] ).

Also, regarding as-needed use of antidepressants, i also think it can work tremendously. After being on high dose Paxil for about 2 years, and then being off drugs for several months (and still feeling like i was experiencing Paxil withdrawal effects-- horrible despair, anxiety, restlessness, and fragmented thoughts), i started taking about 5 to 10 mg Paxil every few days or so, and each day i did that i felt *tremendously* better (although this may have been due at least in part to alleviation of Paxil withdrawal, if indeed i was still under some withdrawal). But yeah, 5 to 10 mg Paxil every few days and i seriously feel great when i took it. However, i imagine tolerance would develop fast if taken every day, and on days i did not take it i would feel terrible again (maybe even worse than normal i think?). Fortunately Nardil has given me every-day relief from that horrible despair and extreme anxiety.
Intersting thoughts/ideas and topic though.


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poster:Questionmark thread:336019
URL: http://www.dr-bob.org/babble/20040412/msgs/336275.html