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Need advice fast--anticholinergics with MAOI's?

Posted by cubbybear on April 10, 2004, at 12:03:54

Would someone maybe be able to shed light on what happened to me today?: I take 30 mg./Parnate daily and have had success with it for 20 yrs. Today, I developed severe stomach cramps without diarrhea or vomiting and a feeling that I had had severe gas and overall stomach/intestinal dstress. The gastroenterologist suspected probable food poisoning (which I didn't think was possible with cramping alone) and what frightened me was seeing that my blood pressure had shot up to 188/120. Since I never had a history of hypertension, I first wondered about a freak hypertensive crisis but then thought it was so unlikely since I had no other symptoms of hypertensive crisis (e.g. headache) and hadn't eaten any of the contraindicated foods with Parnate.
I was given an injection of Buscopan, an antispasmodic/anticholinergic to stop the GI spasms but somehow I felt just as bad, if not worse after this injection. After i got home, I had a (belated) diarrhea attack which lent credence to it being food poisoning, and I felt better after that. Then, I had to contend with a feeling of severe lightheadedness and that I might faint after I got up from the bed and started walking. Perhaps this was a side-effect of the anticholinergic drug or a sign of dehydration, since I hadn't drunk water all day and it was hot and humid.
I read website info about anticholinergic drugs and it says that they adjust the balance of acetylcholine and dopamine. There's no prohibition given vs. MAOIs, so perhaps the lightheadedness was just a side effect. Then, again, what about my earlier HIGH blood pressure? Could food poisoning induce such a thing? I realize that there's a big complex set of factors here, and we're not doctors, but maybe one or more of you can shed light on the BP and anticholinergic questions. Thanks for any help.


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poster:cubbybear thread:334887
URL: http://www.dr-bob.org/babble/20040407/msgs/334887.html