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Re: Partial response to Lamictal - memantine? » SLS

Posted by Emme on April 10, 2004, at 11:57:45

In reply to Partial response to Lamictal - memantine?, posted by SLS on April 9, 2004, at 9:32:30

Hi Scott,

How ya doin'? I am finally trying memantine now. How long has it taken you to notice any improvement? Do you find it very activating? If so, has that faded?

2.5 mg made me jittery. 1.25 still a bit much. I took a break for a few days and now I'm trying 1.25 mg every other day and I've been doing that for about a week. I don't notice any benefit yet. Like you, I have partial response to Lamictal for severe depression in the bipolar spectrum.

I hope your progress continues!

Emme

> Hi.
>
> Just an idea.
>
> I am currently investigating how I respond to memantine (Namenda). I am trying to treat a severe depression that most likely fits somewhere along the bipolar spectrum. I had thought to do this for several reasons, one of which is that I maintain a partial antidepressant response to lamotrigine (Lamictal). Both lamotrigine and memantine possess properties that facilitate the reduction in the activity of glutamatergic neurons, albeit through different mechanisms. It is far too early for me to pronounce the addition of memantine to my drug regime a success, but I am encouraged with how I have been feeling over the last few weeks. I will continue to post of my progress.
>
> It might be that for some of those people treating depression with lamotrigine who maintain a partial response to it, there might be a benefit from the addition of memantine or using memantine as a substitute for lamotrigine.
>
> Crossing my fingers...
>
>
> - Scott

 

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poster:Emme thread:334461
URL: http://www.dr-bob.org/babble/20040407/msgs/334885.html