Posted by rod on March 31, 2004, at 15:44:45
In reply to Re: Biochemistry of OCD and anxiety. What's broken, posted by rod on March 30, 2004, at 3:23:20
> I was reading at www.pubmed.org (search for some studies) that OCD is the opposite neurochemic dysfunction of AD(H)D. According to some papers, OCD brains have an overactive frontal lobe (Hyperglutamergic state), which seems to get corrected by SSRIs. So there is also Glutamate involved.
>
>Just to back up my info, heres the link
"On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11263758----------
1. The objective of the present study was to compare the phenomenology and pathophysiology of obsessive compulsive disorder (OCD) and attention deficit hyperactivity disorder/deficits in attention, motor control and perception (ADHD/DAMP). 2. Through detailed studies of the literature on OCD and ADHD/DAMP, the phenomenology of these two conditions is compared, and possible underlying pathophysiological mechanisms involving interactions between glutamate, dopamine, serotonin and acetylcholine are discussed, with emphasis on OCD. The present paper also discusses possible mechanisms of action for current pharmacological treatments of OCD and ADHD, as well as possible future treatment strategies for these disorders. 3. OCD and ADHD/DAMP are common neuropsychiatric conditions which in many regards appear to be each other's antipodes with respect to clinical manifestations, associated personality traits and brain biochemistry, notably prefrontal cortical glutamate activity. Future pharmacological treatments of these disorders may involve manipulations with glutamate, dopamine D , serotonin 2A and nicotine receptors. 4. It appears that OCD is a hyperglutamatergic and ADHD a hypoglutamatergic condition, with prefrontal brain regions being especially affected.
------Roland
poster:rod
thread:330123
URL: http://www.dr-bob.org/babble/20040329/msgs/330907.html