Posted by King Vultan on March 8, 2004, at 8:16:47
In reply to Re: zoloft and dopamine, posted by dondon on March 7, 2004, at 18:37:14
> Actually I just did some research and found out that zoloft
> is far more potent than bupropion in terms of da
> reuptake. It is also more potent than nomifensine(a drug
> that is used for treating parkinsons when amantadine can't be used or tolerated)
> If a patient with parkinson's disease had to depend on zoloft for symptom relief , they could use 200 mgs of zoloft with
> 30 mg of remeron (blocks 5ht2 and 5ht3) for treating parkinsons
No, Zoloft appears superficially to have superior dopamine reuptake inhibition, but the reality is that its blockade of serotonin reuptake and related adverse effects limit its dosage and consequently its ability to affect dopamine reuptake. The issue of Wellbutrin's metabolites and their blockade of dopamine reuptake is also enormous. This is a link to the article I mentioned earlier.http://www.preskorn.com/columns/0001.html
Todd
poster:King Vultan
thread:321161
URL: http://www.dr-bob.org/babble/20040308/msgs/321978.html