Posted by cornycon on February 21, 2004, at 6:32:11
In reply to Re: Nardil and MAOI diet restrictions » cornycon, posted by Sad Panda on February 20, 2004, at 9:26:09
> > I have come across some research that may be of interest. The drug Selegiline ( Eldepryl. Deprenyl) is selective for MOA type B, which is the accepted triggering agent for the Tyramine reaction. It appears that with small doses of this drug the MOAB levels are inhibited to the extent that significant levels of Tyramine can be tolerated before there is any reaction.
> Below 20mg/day you don't need to be on the diet, but being an MAO-B inhibitor means that it doesn't increase the levels of Serotonin or Norepinephrine which makes it not an anti-depressant. Above 20mg/day makes it no longer selective & you have to be on the diet. It will be awhile before we get to see the patch.
> "In controlled clinical trials, selegiline caused slight improvement in motor performance at the start of therapy and worsening at its discontinuance; it also delayed the development of disability that requires the addition of levodopa. Selegiline was approved by the FDA in June 1989."
> In Australia you can't have Selegiline until AFTER you are on levodopa--decarboxylase inhibitor combinations. We are a backwards country.
The suggestion of Selegiline was purly for its inhibitor effect and as adjunct to the other meds. With the med streams that are currently in place the manifest benifits that would ensue from investigation of the effect and what other meds could be used along with it seem to be a pipe dream of the desperate diet restricred nail biting people stuck with the narrow minds of the med profession that wants to avoid any possibility of legal repercussions.