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Re: Transdermal selegiline (EMSAM) marked approvable

Posted by Chairman_MAO on February 2, 2004, at 11:20:23

In reply to Transdermal selegiline (EMSAM) marked approvable, posted by jrbecker on February 2, 2004, at 10:32:27

I'm pleased that my cynicism wasn't correct and this was approved. I will be one of the first people in the EmSam line when it hits pharmacies. Finally, we are moving beyond first generation MAO inhibitors in the US. Only took five decades!

BTW, has anyone here ever supplemented selegiline with raw cacao powder (as a source of phenethylamine, which is extremely hard to buy unless you are a research institution)? I bought it in capsules (Nature's Way) and found that a few grams of cacao combined with selegiline produced a pleasant, amphetamine-like effect without the sympathetic nervous system activation.

I will no doubt be eating more chocolate when that patch rests upon my body. :)

Sustained antidepressant
effect of PEA replacement
by
Sabelli H; Fink P; Fawcett J; Tom C
Rush University and the Center for
Creative Development, Chicago, Illinois, USA.
J Neuropsychiatry Clin Neurosci, 1996 Spr, 8:2, 168-71

ABSTRACT

Phenylethylamine (PEA), an endogenous neuroamine, increases attention and activity in animals and has been shown to relieve depression in 60% of depressed patients. It has been proposed that PEA deficit may be the cause of a common form of depressive illness. Fourteen patients with major depressive episodes that responded to PEA treatment (10-60 mg orally per day, with 10 mg/day selegiline to prevent rapid PEA destruction) were reexamined 20 to 50 weeks later. The antidepressant response had been maintained in 12 patients. Effective dosage did not change with time. There were no apparent side effects. PEA produces sustained relief of depression in a significant number of patients, including some unresponsive to the standard treatments. PEA improves mood as rapidly as amphetamine but does not produce tolerance.


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poster:Chairman_MAO thread:308481
URL: http://www.dr-bob.org/babble/20040131/msgs/308495.html