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Re: Geodon ...

Posted by Questionmark on January 23, 2004, at 1:44:45

In reply to Geodon experiences and specifically sexual side fx, posted by Betternow on January 22, 2004, at 22:15:30

> Are SSRI sexual side effects mediated through 5ht2a agonism?
Yes, it's believed to be primarily caused by 5-ht2a agonism.
> If so would Geodon as a ssri and a 5ht2a antagonist be efficacious without the sexual side effects?

Wow, does it have those properties? i would assume the answer to your question to be "yes" then. Do you happen to know all of Geodon's neuropharmacology/ receptor activities? i would love to know this-- for all the atypicals actually. But if there is significant NE, or especially, dopamine receptor antagonism, it might not be that good an antidepressant. Also alot of times 5-ht2a antagonism seems to counteract the beneficial effects of SRIs. So i'm not sure.


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poster:Questionmark thread:304434
URL: http://www.dr-bob.org/babble/20040122/msgs/304490.html