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Re: wellbutrin vs. remeron » JohnX2

Posted by MoBe on January 16, 2004, at 19:46:31

In reply to Re: wellbutrin vs. remeron » mike21, posted by JohnX2 on February 26, 2002, at 20:51:24

>
> Mike,
>
> Your pdoc prescribed both?
>
> While its hard to predict precisely how medicine
> would react in concert in the brain, logic would dictate
> that you would want them to work synergistically to
> get an additive effect.
> As such, I have always felt that a Remeron/Wellbutrin
> type combo would have "interference". But there no real clinical
> data to back it up. You don't really hear of too many
> people trying that combo. I'm aware of a number of
> noradrenergic medicines that increase firing in the locus
> coeruleus and others that inhibit firing, there projections
> from that nucleus is where a lot of the anti-depressant mechanisms
> occur. I would see a "conflict of interest" if you combined to
> medicines trying to do the opposite thing. Just my opinion
> I could be wrong, but you came to the same independant conclusion.
>
> Good luck with your medicines.
>
> Frankly I think the Remeron may make the Wellbutrin
> quite anxious feeling. I guess Im thinking the Wellbutrin
> may enhance the Remerons effect, but it would kill the
> Wellbutrins mode of action. (Id explain but Im tired).
>
> Regards,
> John
>
>
> > >
> > > In regards to Wellbutrin, the medicine long term inhibits
> > > firing in an area of the brain called the "locus coeruleus".
> > > This is a central noradrenergic nucleus that is very sensitize
> > > to stress. Wellbutrin has metabolites that are potent norepinephirine
> > > reuptake inhibitors that long term desensitize the alpha-2 feedback
> > > receptors in this area of the brain which causes the firing rate to
> > > slow down. This causes a net increases in norephinephrine in the synapse
> > > with a slower firing rate. The slower firing rate gives reduced anxiety.
> > > But it takes time for the alpha-2 feedback receptor to be downregulated.
> > .
> > .
> > .
> > > You can really increase the power of Jumex by taking Remeron,
> > > but you are playing with fire and will be really anxious.
> > > The Remeron antagonizes the alpha-2 feedback receptor and I think will
> > > increase the tyrosine hydroxylase enzyme. This
> >
> >
> > It seems that remeron would actually block wellbutrin from performing its main action: desensitizing the alpha-2 feedback receptor. I was recently prescribed both, but am now questioning the point of using both at once. I guess it could be that the wellbutrin is somehow meant to augment remeron and some of its side-effects. What are your thoughts?
> >
> > Mike
> Hi Mike and JohnX2
I read your comment on Wellbutrin that "This causes a net increases in norepinephrine in the synapse with a slower firing rate. The slower firing rate gives reduced anxiety." From this I take it that if a person has insomnia because of anxiety, after a while, the anxiety and the anxiety induced insomnia will be less when on the wellbutrin. I know this would take time, but how much time?
Thanks
MoBe
>


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