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re: atypical NMS » maxx44

Posted by Larry Hoover on January 3, 2004, at 10:49:26

In reply to re: atypical NMS, posted by maxx44 on January 2, 2004, at 18:18:18

> search 'neuroleptic malignant syndrome' (NMS), and 'atypical NMS'---when drs. speak of any neuroleptic they use a phrase, 'dopamine and/or dopamine serotonin' BLOCKADE---this is a misnomer as these drugs don't 'block' anything, rather Demolish the deep-brain production facilities and receptors of these key elements of 'self'. that's why those having used benzos or worse, neuroleptics, usually long-term but often even briefly, suffer the fate of always needing the drug. their born 'hardware' has been 'wiped'. scary? please, don't kill the messenger, as many would.

Well, I have no intention in killing the messenger, but I hope you won't mind if I challenge your declarations, and seek further information from you.

Quite contrary to what you declare above, neuroleptic malignant syndrome is generally associated with any drug which binds to the D2 dopamine receptor. There are exceptions, and those cases are considered to be idiosyncratic (due to factors present in the individual).

The total incidence of NMS is estimated to be 2 cases in 1000 (for all antipsychotic meds), and is generally accepted to be substantially less for the newer, so-called atypical antipsychotics, although data have not yet been sufficient for a numerical estimate.

NMS occurs 2/3 of the time within the first week of treatment, and almost without exception, within the first 30 days of treatment. Moreover, with appropriate medical care, the condition is considered to be fully reversible, upon discontinuation of the offending drug. There seems to be a trait susceptibility factor at work, so that those subjects having had one such occurence are substantially more likely to have another.

For more details, see:
http://www.nmsis.org/general_information.shtml

The immediate occurrence of NMS (upon initiation of drug therapy) argues very much against your proposed "Demolish(ing of) the deep-brain production facilities and receptors of these key elements of 'self'", as does the immediate recovery therefrom. Moreover, neurotransmitters cannot, by any stretch of the language, be construed to be "key elements of 'self'".

Your experience with drugs in this class may well have been horrific, and I deeply sympathize with you. However, you cannot generalize from your experience to the population as a whole. In fact, despite more than forty years of observation and study of NMS, we still do not know what causes it, or why it strikes the individuals that it does.

I do appreciate that informed consent requires, obviously, that one become informed. However, disseminating hyperbole and exaggeration does not qualify. In the context of the experience of the population as a whole, NMS remains a rare occurrence. It is a risk of neuroleptic treatment (and a few other drugs, as well), and if patients read the information kit that should accompany any new prescription, they will be fully apprised of the symptoms of concern, as well as the need to seek emergency treatment should those symptoms occur. After one month has passed, one can reasonably stand down from that guarded stance.

Now, as to having the "hardware wiped".....

The hardware, receptors and neurotransmitters etc.???

I'm not even sure of what you speak of.

The only way that a permanent change can be effected is to have the DNA destroyed, or changed. All cells are constantly interacting with their environment. Everything outside an individual cell is environment to it.

Within a cell, everything is environment to the DNA.

The DNA actively modifies its environment, via mechanisms not yet known to us. Some genes will become more active, while others become less so, due to environmental clues. Unless the cell dies (Parkinson's disease is the death of very specialized dopamine-secreting cells in the substantia nigra, for example), it will respond to external clues in accordance with its own genetic complement.

If there is a sudden external change (drug initiation, or drug withdrawal, for example), there will be a lag time between the way the cell was set up to deal with the environment, until it can find a new comfortable way to deal with the environment. During that period of adaptation, there can be some (very) unpleasant experiences. In so many words, it takes time for the DNA to figure out what's going on external to it, and to adapt the cell to the new parameters.

Now, let's consider the use of benzodiazepines. Let's also assume they're used by someone with a reasonable argument for using them in the first place, e.g. anxiety interfering with their quality of life.

For many such people, long-term benzo use is the norm. But, over time, efficacy can diminish, or medical situations may develop, such that discontinuation of the med is required. (I'll ignore the presently commonplace benzophobia overcoming the medical establishment. That is an issue worthy of an essay, in and of itself.)

A person undergoing such withdrawal is very likely to have profound symptoms, characteristic of the opposite of the effects of the drug itself, so-called rebound phenomena. There may also be other unique effects of withdrawal.

Now, that person will not go back to being "normal" after withdrawal. They were, after all, experiencing quality of life (anxiety) issues in the first place. Moreover, it is entirely possible that their "disease" (I think the word is appropriate, as 'disease' arises from the Old French, diseasu, "not at peace"), can reasonably have progressed (the anxiety likely worsened over time, causing the individual to seek treatment initially, and aging has occurred during treatment), despite medical intervention, via benzos. There is ample reason to expect that such a person will be particularly uncomfortable after withdrawal of the benzo medication. To attribute such an experience to, how did you say it?, 'hardware' (having) been 'wiped', is without foundation, and smacks of fear-mongering.

Please do provide any information that you can about hardware wiping and demolished deep-brain production facilities, as I would very much like to become an informed consumer myself.

Regards,
Lar

 

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poster:Larry Hoover thread:13781
URL: http://www.dr-bob.org/babble/20031231/msgs/296006.html