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Re: Shaky hands - how to explain to people? » Laree

Posted by scott-d-o on December 23, 2003, at 15:30:37

In reply to Re: Shaky hands - how to explain to people?, posted by Laree on December 22, 2003, at 21:20:36

> Scott, I am on Wellbutrin SR 200 mg./day & Adderall 50 mg./day. Do you think these are a bad combination? Thanks!

I wouldn't say any combination of meds is intrinsicly a bad combination because they all work differently for everyone. I'm sure you know what works best for you. I was merely trying to make a suggestion as to why the original poster might be having problems with shaking.

In my experience, this shaking is caused by low dopamine, or too high serotonin, norepinephrine, and acetylcholine. Dopamine inhibits involuntary movements such as these and acetylcholine excites them. People with Parkinson's disease have a compromised dopamine system, therefore acetylcholine overpowers it, causing them to shake. Fortunetly in this case it is a temporary condition that can be overcome whereas Parkinson's is caused by irrepairable damage to dopamine neurons.

Another solution besides increasing dopamine transmission is to take a small amount of the over-the-counter antihistamine diphenhydramine. It is an acetylcholine muscarinic antagonist and is used in many sleep aids available over the counter. Antihistamines are also used for Parkinson's on occasion for this anticholinergic action.


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poster:scott-d-o thread:289864
URL: http://www.dr-bob.org/babble/20031219/msgs/292865.html