Posted by timidly on December 10, 2003, at 19:35:49
In reply to Re: Combination of MAOI and Abilify, posted by gardenergirl on December 9, 2003, at 22:37:39
> I just ran your list of meds on a program I have for my Palm called Epocrates. It did not show any interactions between Abilify and Nardil; however, there were a few interactions on your other meds you may already be aware of:
> Nardil and trazodone: contraindicated; combo may increase risk of serotonin syndrome (additive/synergistic effects)
> Abilify and trazodone: caution advised. Combo may increase risk of CNS depression; psychomotor impairment
> Metatdate ER and Nardil: Contraindicated: combo may result in hypertensive crisis (synergistic effects).
> Don't mean to alarm you, but when on multiple meds, there is a lot to consider. The program on my palm gets updated from the web daily. It could have mistakes, but better safe than sorry. Is your pdoc experienced in combining meds? You seem to be on a high dose of Nardil. I'm worried that you are at much more risk for nasty side effects.
> Recalcitrant depression can be a real challenge. I hope you find a safe, and more importantly, effective combination that works for you!Thank you very much for the information. I am very aware of the Nardil/Ritalin contraindication, as is my pdoc (and as were all my previous pdocs). Prior to starting the Nardil I had labile hypertension. My BP became rock solid at 120/80 after starting the Nardil. I still remember vividly when Dr. Hugh MacNamee at Dartmouth-Hitchcock Medical Center first started me on the combination 25 years ago. After signing informed consent, I spent the better part of a day in a room with my vital signs continously monitored when I took the first dose of 1.25 mg, then 2 hours later another 2.5 mg, then another 2 hours later another 5 mg. My Blood Pressure remained rock solid. My BP was monitored twice daily for a week, then daily for 3 months. I have now been on the combination of Nardil and Ritalin for 25 years and my BP is still rock solid.
I was not aware of the contraindication between Nardil and Trazodone, and I will definitely check into that.
My pdoc got the okay from my pharmacist before giving me the Abilify samples yesterday afternoon. Last night I got a call from my pharmacist telling me not to take any Abilify yet, stating they had found some contraindications for medications with somewhat similar effects in the brain, and that they were waiting for a response from pharmaceutical company. My pdoc called me a few minutes ago and told me that there was no safety information about the combination of Abilify and MAOIs, and that he was not willing to take the risk. He told me not to take any Abilify, that he would try Lamictel instead.
poster:timidly
thread:288195
URL: http://www.dr-bob.org/babble/20031208/msgs/288562.html