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Re: HELP - BUSPAR, part 2: total confusion!

Posted by Tony P on December 4, 2003, at 3:48:03

In reply to Re: HELP - BUSPAR, part 2: total confusion!, posted by scott-d-o on December 2, 2003, at 22:54:22

> Scott: [much good info clipped] I believe people attribute buspirone's antidepressant activity to its metabolite, 1-PP, which is a NE alpha2 antagonist (i.e. yohimbine), which are presynaptic and increase the release of norepinephrine. ... This metabolite is actually found in much greater concentrations in the blood after buspirone than the unchanged drug itself. Hope this helps.
> Scott

That probably explains why I always get the activating effect about 2 hours _after_ taking Buspar, when the slightly dopey feeling wears off. BTW, I have always had an immediate activating and stress-reducing response to Buspar, although it's a moot point now since I take it regularly (20-30mg/day).

It used to _prevent_ me from sleeping, so I always took it morning & noon, but lately it has made me sleepy if I am lying down in a quiet place. Our bodies just keep on adapting....





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