Re: Buspar

Posted by linkadge on November 30, 2003, at 18:29:03

In reply to Re: Buspar, posted by SLS on November 30, 2003, at 14:25:42

That is true, it is both a post synaptic and presynaptic agonist. So by activating the post synaptic receptors it has antidepressant activity, but by activating the presynaptic receptors it decreases overall serotogenic function. Presumably, is anxiolitic profile is a result of decreased activity at the 5ht2a receptor (acivation of this receptor is presumably why SSRI's can cause anxiety).
Linkadge

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