Posted by mtdew on November 18, 2003, at 16:38:19
In reply to Neurotoxicity - SSRI's may not be so benign..., posted by Sean on April 13, 2000, at 16:38:21
All,
Here is the reference for the article Sean mentions:
Comparative study of fluoxetine, sibutramine, sertraline and dexfenfluramine on the morphology of serotonergic nerve terminals using serotonin immunohistochemistry
Brain Research, Volume 858, Issue 1, 6 March 2000, Pages 92-105
Madhu Kalia, James P. O'Callaghan, Diane B. Miller and Michael KramerIt can be purchased for $30 from www.sciencedirect.com. Well worth the money, I think.
Neal
>
> I've read the entire article (in Brain Research)
> about the comparative effects of fluoxetine, sertraline,
> Meridia, Redux, and MDMA on serotonin producing cells.
>
> It was found that *all* of these drugs produced a
> characteristic change in the cells described as
> "corkscrew shaped" and "swollen axons". What this
> really means is unkown at the moment, but it doesn't
> sound very encouraging to me.
>
> In any case, taking drugs is always an ethical trade
> off with risks and benefits. This goes for both legal
> and illegal drugs. Personally, I would stay away
> from MDMA. On the other hand, I know people who
> took gobs of the stuff when it was legal and they
> seem absolutely fine. Of course they may become
> depressed or prematurely senile in the future due
> to lasting damage in certain brain areas. I think
> the risks of MDMA are not worth the results. This
> is especially true for people with a tendency towards
> anxiety or depression and may already have vulnerable
> neurons....
>
> Sean.
>
>
>
>
>
>
> > I went to the Doctor to get Prozac for ecstacy Neurotoxicity (but said for depression), but instead of getting Prozac I was given Cipramil (citalopram hydrobromide).
> >
> > Is it the same as prozac ??? Will it prevent neurotoxicity ???
> >
> >
> > It has been proven that Prozac will fully prevent Neurotoxicity of ecstacy (MDMA).
> >
> > Administering Prozac (fluoxetine) up to six hours after the MDMA prevents the neurotoxic damage. We know that Prozac plugs the reuptake transporters. Since it prevents the damage even if administered six hours after the MDMA, this indicates that it is not the MDMA per se that causes the damage, but something which enters the reuptake transporters after the serotonin is depleted, most likely dopamine (see the slideshow for more details.) Without the protection of prozac, the damage seems to occur slowly over the course of a 24 hour period.
>
>
poster:mtdew
thread:29745
URL: http://www.dr-bob.org/babble/20031116/msgs/280932.html