Posted by smittay17 on November 17, 2003, at 15:05:21
In reply to Re: HELP ME: Whats the ratio of Sero/NE in Imipramine? » smittay17, posted by Larry Hoover on November 17, 2003, at 9:43:55
> > Ive been on imipramine since 1996 (200mg). My psychiatrist wants me to get on celexa and desipramine to avoid TCA side effects. Since desipramine is a TCA and celexa is an SSRI.
> >
> > He thinks Imipramine is 3/4 serotonin and 1/4 Norepinephrine.
>
> Close enough.
>
> > Can someone please help me out? I'm in the process of changing right now from imipramine to celexa and desipramine...and could really, really use some help
> >
> > I'm afraid this ratio thing isn't correct cause i'm not feeling too well right now :(
> >
> > Please if anyone knows can you post?
> >
> > Thanks,
> > Erik
>
> How geeky an answer are you looking for?
>
> http://www.preskorn.com/columns/0003.html
>
> http://jpet.aspetjournals.org/cgi/content/full/283/3/1305
>
> Your new drug combo is much less noradrenergic, in my opinion.
>
> LarLarry
Thanks so much for your help. I have a really horrible problem. My imipramine is causing my tongue to swell to 2X its size (because its s TCA) and causing sleep apnea and i have to wear an oxygen mask to bed and i'm only 28. So the ratio is really around 75% serotonin and 25% NE?
My doc wants me to get on less of a dosage of a TCA so this won't happen. So he suggested to get the NE from 50mg of desipramine (still TCA but not as much) and to get the serotonin from 40mg of celexa.
Do you think this will work? Do you know of a better suggestive combination? I tried just Celexa and couldnt do it, so I obviously need some NE. I tried Remeron and I balooned up (i dont think that would help the Apnea).
Whats the closest thing I could get to that like the Imipramine wihtout the TCA side effects?? I guess i dont understand where the difference between tcas and ssris work. is TCA the pre-synaptic nerve?
Thanks so much for helping me Larry, i'm having a horrible time managing this, no sleep, and working a corporate job...people just don't realize how hard this stuff is! :)
poster:smittay17
thread:280491
URL: http://www.dr-bob.org/babble/20031116/msgs/280578.html