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Re: ¿VALCOTE sube los niveles plasmaticos de ZYPREXA?

Posted by Bill LL on October 21, 2003, at 9:38:51

In reply to Re: ¿VALCOTE sube los niveles plasmaticos de ZYPREXA? » BORN-IN-CHILE, posted by Mariposa on October 20, 2003, at 19:05:41

I did some internet searches. It looks like Valcote (Depakote) is used in combination with Zyprexa. I copied a couple of articles.

Thanks for the translation!

5. Double blind study to assess the safety and efficacy of valproic acid (Depakote®), an anticonvulsant, in combination with an atypical antipsychotic medication versus the use of either the antipsychotic alone in the treatment of psychosis in hospitalized patients with schizophrenia. During the four-week study, patients will be randomly assigned to one of four groups receiving the following medications: valproic acid plus risperidone (Risperdal®), valproic acid plus olanzapine (Zyprexa®), risperidone plus placebo, or olanzapine plus placebo.

Figure 10 outlines the cost-benefit analysis for various agents used in bipolar disorders.
Figure 10
Valproic Acid (VPA)
If GI Disturbance
Divalproex
(Depakote)
Lithium
Carbamazepine
Geodon
Equivalent Standards of Care
Use of Agents for Bipolar Disorder
(Cost-benefit Analysis))
OR
Risperdal
($0.17)
($1.36)
OR
Zyprexa
Other
Benzodiazepine
Lorazepam
(Ativan)
ADD
OR
*
*
If needed, add
Next
Next
Note: Sequential additional of
drug based upon client's
response


> > ES CONOCIDO QUE LOS ANTICONVULSIVANTES , POR EJEMPLO CARBAMAZEPINA, BAJA LOS NIVELES PLASMATICOS DE OTRAS DROGAS ENTRE ELLAS ZYPREXA, SIN EMBARGO EN ALGUNA OPORTUNIDAD APRENDI QUE VALCOTE( DIVALPROATO DE SODIO ) SUBIRIA LOS NIVELES PLASMATICOS DE LA OLANZAPINA ( ZYPREXA ) , Y DE HECHO, EN MI PRACTICA CLINICA , DE ESA FORMA PUEDO NO AUMENTAR A DOSIS DEMASIADO ALTAS DE ZYPREXA, CUANDO EXISTEN PROBLEMAS ECONOMICOS ¿ ALGUIEN TIENE INFORMACION O CONOCIMIENTO DE LO QUE EXPONGO ? GRACIAS
>
> I'll take a stab at it ....
>
> It is known that anti-convulsants (sp), for example Carbamazepina, below the Plasmatic(?) levels of other drugs among them Zyprexa, although in some oportunity I learned that Valcote (???????? of sodium) will raise the plasmatic levels of Olanzapina (Zyprexa), therefore, in my clinical practice, in that way I can keep from raising the dosage of Zyprexa too much, when economic problems exist. Does anyone have information or knowledge of what I am proposing? Thanks.
>
>
> Please be aware I have done a *literal* (word for word) translation for you which may or may not totally convey the essence of the message....Hopefully they will respond as you have asked.~~~8|8


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poster:Bill LL thread:270082
URL: http://www.dr-bob.org/babble/20031021/msgs/271414.html