Posted by Robert Fairburn on October 3, 2003, at 17:41:52
Has anyone found that nearly all tricyclics dont work for them but one or two SSRI agents do. the fact that some classes of drugs seem to work for some people yet other classes of anti-depressant drugs make things worse has made be put some thoughts down.
I am wondering if there is a sub class of poeple that only find SSRI effective. I know that lots and lots of people respond well to tricyclic drugs. Im just wondering if there are large number of chemical imbalances. Hence the large number of different reactions to various meds
Here is a possible listing of chemical imbalances and why some drugs work and why some don't
Type 1 People who are low of norepinephrine either in receptor cell sensitivity of production of neropinephrine (These people should respond well to tricyclics that increase neropinephrine)
But respond poorly to SSRI drugsType 2 People who are low in seratonin or have low seratonin receptor sensitivity ie too few receptors or the receptors themselves are insensitive) These people should respond well
To ssri drugs best but get some effectiveness from some tricyclicsType 3 People who are low in both neropinephrine and seratonin. I would think that such a person is very depressed. These people might respond to Effexor or high doses of tricyclics I would suspect that they would find SSRI drugs less effective
Type 4 people high in Norepinephrine or have a large number of norepinephrine receptors, but have low levels of seratonin. These people are aggrevated by tricyclic drugs but not SSRI drugs. Might be the problem with some anxiety disorders such as GAD or panic attacks
Type 5 People who have high levels of seratonin or receptor cell sensitivity This condition might be a rare condition but might explain why buspar works on some people who have anxiety problems
For all you backyard biochemist out there please comment
poster:Robert Fairburn
thread:265309
URL: http://www.dr-bob.org/babble/20030928/msgs/265309.html