Posted by Ame Sans Vie on September 28, 2003, at 8:28:51
In reply to Amphetamine tolerance, DXM, NDMA blocking, posted by btnd on September 26, 2003, at 13:20:37
Near the end of this document are the recommended dosages of the NMDA antagonists methadone, dextromethorphan, and ketamine. Note that the higher end of the suggested daily dose of DXM is 1,000mg!!! That seems a bit... crazy. But it implies that you should begin with 15-30 dextromethorphan polystirex (Delsym -- extended release forumulation) three times daily.
I'm not finding anything specifically addressing the issue of NMDA-antagonists for amphetamine tolerance, but I did come across a lot concerning their use to potentiate and prevent tolerance to opioids as well as the potential for them to have such an impact upon dependence/tolerance in general. The first thing I found interesting is a novel drug called MorphiDex, currently undergoing research, which is a 50/50 combination of morphine and DXM. This study strongly supports its ability to increase analgesic effectiveness of morphine:
http://opioids.com/morphidex/index.html
I'm also inferring from the study that the researchers must consider DXM safe taken long-term. I mean, assuming 80mg morphine qid, we're talking 320mg of DXM daily -- still quite a bit shy of the gram recommended above, but 320mg is (for most people) a very psychoactive dose. I'm only taking 15mg and definitely feel it helps. I can't explain my lack of Ultram tolerance after 400mg/day for several months any other way.
poster:Ame Sans Vie
thread:263518
URL: http://www.dr-bob.org/babble/20030928/msgs/263886.html