Posted by Ramon Paz on September 23, 2003, at 20:31:12
In reply to Effexor SSRI/SNRI nonsense, posted by linkadge on September 23, 2003, at 20:15:20
> I've heard many people around here say things like Effexor is an SSRI in small doses, and then is an SNRI at higher doses.
>
> This makes no sence at all. Effexor blocks the reputake of serotonin and norepinephrine in a certain ratio, dose dependantly.
>
> Even if you only take 37.5 mg of Effexor, you are still getting a certain reputake of serotonin and a certain reputake of norepinephrine. Effexor is an SNRI at all doses.
>
> The issue comes when describing the effects of Effexor. For me, and some others, Effexor is quite stimulating even at 37.5mg. For others (who may have a lower norepinephrine to begin with) they may need higher doses to achieve adequate norepinephrine reputake inhibition.
>
> But saying things like Effexor has no effect on Norephinephrine until 225mg's makes no sence. If the molecue has affinity for norepinephrine reputake sites then it will increase norepinephrine levels dose dependantly.
>
> I agree the effects of the drug are dependant on the person. Some say it makes them drowsy, but I couldn't keep still on the stuff.
>
> LinkadgeEffexor is classificated as SNRI, so it is SNRI.
What you said about noradrenergic and even dopaminergic effects is right. But if you're tanking 75mg you wont fell norad effecs so the designation used. Did I say a bullshit?
I read(just read) the proportion is 10:5:1 seroton,norad,and dopaminergic. (milnacilpran is 1:1)
poster:Ramon Paz
thread:262767
URL: http://www.dr-bob.org/babble/20030923/msgs/262775.html