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Re: Need some SSRI with your Effexor?

Posted by linkadge on August 29, 2003, at 15:00:56

In reply to Need some SSRI with your Effexor?, posted by Bill L on August 29, 2003, at 12:07:07

I think the problem is that we don't have the correct combination of serotonin and norepineprine in our antidepressants.

Even though Effexor has somewhat lesser effects on Serotonin than on norepinephrine, I still beleive its norephiniephrine effect is too strong. Many find it too stimulating, thats why they switch to a SSRI.

But SSRI's on the other hand can sometimes cause apathy because of norephinephrine downregulation.

This is perhaps why a combination of the two has proved to be so useful. Because you can boost the serotonin effect and still retain some norepinephrine effect.


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