Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Klonopin for Adderall tolerance? btnd

Posted by Larry Hoover on August 25, 2003, at 6:38:55

In reply to Klonopin for Adderall tolerance?, posted by btnd on August 25, 2003, at 0:42:46

> Many studies have indicated that amphetamine (Adderall/Dexedrine/Desoxyn) tolerance is prevented by exogenous or endogenous agents that are able to inhibit excess Ca++ influx into the neuron through the gated calcium channels on the neuronal membrane that have NMDA subtype glutamate receptors.
> Taken from the last study I've posted on Klonopin (clonazepam) working together with NADH (or actually increases NADH). The conclusion is:
> "...We conclude that clonazepam is an effective inhibitor of mitochondrial [Ca2+] efflux in intact cells."
> Do you think Klonopin could be used to prevent amphetamine tolerance? Am I right again? :)

Not this time, as I read these bits.

> Take care.

The first scenario is modulated by calcium influx into neurons, i.e. from the intercellur space. The second scenario involves mitochondrial calcium efflux, i.e. into the intracellular fluid.
The former, flow into a cell from outside. The latter, flow out of an organelle, but still in the cell.





Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Larry Hoover thread:253534