Posted by brender on August 23, 2003, at 18:30:08
In reply to Brender - regarding urinary acidification, posted by BekkaH on August 23, 2003, at 1:59:29
> Hi. Substances that acidify the urine will
>hasten the urinary excretion of amphetamines. I
>don't think that is necessarily the same thing
>as "lessening the potency." If you acidify the
>urine and hasten urinary excretion of
>amphetamines, you might need another dose
>sooner than you would have otherwise, and
>tolerance will develop sooner than it would have
>otherwise....Hi,
I just read this on GlaxoSmithKine's website in the product info for dexedrine (of course I'm taking generic, but I'm sure it applies):
"Drug Interactions
Acidifying agents—Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid
HCl, ascorbic acid, fruit juices, etc.) lower absorption of amphetamines. Urinary acidifying
agents (ammonium chloride, sodium acid phosphate, etc.) increase the concentration of the
ionized species of the amphetamine molecule, thereby increasing urinary excretion. Both groups
of agents lower blood levels and efficacy of amphetamines."
(http://us.gsk.com/products/assets/us_dexedrine.pdf)So, I'm assuming this means that if I take a bunch of ascorbic acid (I'm thinking emergen-C) with my meds, it will be somewhat similar to taking a smaller dosage and not run the risks you described...I hope...do you think that's a good assumption?
poster:brender
thread:253149
URL: http://www.dr-bob.org/babble/20030823/msgs/253441.html