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Re: Severe dopaminergic neurotoxicity w/ MDMA stjames

Posted by MB on July 25, 2003, at 22:00:49

In reply to Re: nah, this is important. wouldnt do something like, posted by stjames on July 21, 2003, at 14:44:22

> In over 200 doses I have no neurotoxicity. Given that ecstacy has been around for decades, you would think this "neurotoxicity" would be well reported.

Another article

Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy").

Science 2002 Sep 27;297(5590):2260-3 (ISSN: 1095-9203)
Ricaurte GA; Yuan J; Hatzidimitriou G; Cord BJ; McCann UD
Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

The prevailing view is that the popular recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") is a selective serotonin neurotoxin in animals and possibly in humans. Nonhuman primates exposed to several sequential doses of MDMA, a regimen modeled after one used by humans, developed severe brain dopaminergic neurotoxicity, in addition to less pronounced serotonergic neurotoxicity. MDMA neurotoxicity was associated with increased vulnerability to motor dysfunction secondary to dopamine depletion. These results have implications for mechanisms of MDMA neurotoxicity and suggest that recreational MDMA users may unwittingly be putting themselves at risk, either as young adults or later in life, for developing neuropsychiatric disorders related to brain dopamine and/or serotonin deficiency.




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