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Re: Cymbalta/Duloxetine timing

Posted by pseudonym on July 21, 2003, at 13:44:22

In reply to Re: Cymbalta/Duloxetine timing, posted by JLM on July 21, 2003, at 1:49:52

Manipulating SE and NE is such a broad and diverse area of research. Your dismissive statement of "just manipulating SE and NE" seems to conclude that any research into these two neurotransmitters is a failed avenue of research. Wrong.

For one, duloxetine has much lower K(i) values, which indicates it prevents re-uptake much more potently than Effexor, in vivo. Furthermore, it takes a lot less of it to do so, as indicated by much lower ED-50 values. Finally, it prevents re-uptake of NE at much lower dosage levels than Effexor. The clincal trial data is also promising, but I'm not going to reiterate that here. My prediction: You're going to come back with a mea culpa in 6-9 months, and be happy to do so.


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URL: http://www.dr-bob.org/babble/20030718/msgs/243924.html