Posted by SLS on July 17, 2003, at 11:49:55
In reply to Re: Anybody try SIBUTRAMINE (Meridia) for depression?, posted by jrbecker on July 17, 2003, at 11:34:46
> However, I do know that Sepracor is in Phase II trials for a sibutramine metabolite for depression, but is currently on hold due to budgetary constraints.
Hi JB.
Thanks for the heads-up. I found the following:
"Sepracor's (R)-sibutramine metabolite is an isomer of an active metabolite of Abbott's MERIDIA®. The (R)-sibutramine metabolite has been shown in preclinical studies to be a potent norepinephrine, dopamine and serotonin reuptake inhibitor. The compound's unique triple mechanism of action may provide a broader spectrum of therapy than other currently marketed antidepressants. Physicians often prescribe various combinations of drugs to achieve similar outcomes, indicating a need for this potential therapeutic synergy."
This sounds great.
"The (R)-sibutramine metabolite development program for refractory depression is on budgetary hold due to resource constraints."
This sounds not-so-great.
Are you aware of any DA reuptake inhibitors in the R&D pipeline? Nomifensine helped a great many people before it was discontinued.
What's your take on the sibutramine controversy? Do you think the FDA will pull the drug from market?
- Scott
poster:SLS
thread:242854
URL: http://www.dr-bob.org/babble/20030714/msgs/242868.html