Posted by jrbecker on June 21, 2003, at 11:56:37
In reply to Re: BPD, GRK, and dopamine, posted by SLS on June 16, 2003, at 15:58:44
Scott,
a little more info on your original questions about GRK-3. First, GRK-3 is a g-coupled protein receptor kinase (I failed to answer this question the first time round). And secondly, as I mentioned before, in instances of bipolar I, it is theorized that there is a lack of GRK-3, and thus, a susceptibility to excess dopamine and other neurotransmitter activity. Where as in Bipolar II, contrastingly, there might be somehow an inability to turn GRK-3 off -- or perhaps more of the dyfunctional psyhogenes for BP II lie altogether elsewhere. This is echoed in Kelsoe's subject findings: "in four human subjects, reduced GRK3 expression corresponded with bipolar I, while the other two subjects not showing a GRK3 decrease had bipolar II."
By the way, this link goes a little further into some of the other gene locations they thought were suspect as well.
http://www.mcmanweb.com/article-89.htm
Give thanks to John McManamy for being there to do first-hand reporting for all of us.
poster:jrbecker
thread:234222
URL: http://www.dr-bob.org/babble/20030619/msgs/235841.html