Posted by Caleb462 on June 16, 2003, at 11:57:04
In reply to Re: Obsessively looking » BekkaH, posted by Questionmark on June 16, 2003, at 4:46:34
> First, Caleb, you said "Clomipramine is also a 5-HT2a antagonist. Thus you get multiple Anti-depressant/Anti-obsessional effects from the same drug." i thought 5-HT2 (including 5-HT2a i think) agonism helps obsessive-compulsive tendencies and 5-HT2 antagonism aggravates OC stuff. Am i wrong on this or are you (/him)? Please, i'm really curious about this.
Well... it's complex. There has been some information that 5-HT2a agonists may help OCD - because there are many ancedotal reports of LSD and other 5-HT2a/c agonists alleviating OCD symptoms. And atypical anti-psychotics have been shown to worsen OCD when used alone - without an SRI. When an SRI and a 5-HT2 blocker are combined, however, there doesn't seem to be any problem - and indeed, it seems to boost the anti-obsessional effects.
> BekkaH said:
> > "I was much more obsessive-compulsive when I was on Adderall. It was so bad that it was completely counterproductive. Some people report "hyper-focusing" on Adderall, and I noticed that as well, although I referred to it as "fixation" more than "hyper-focusing," but it's essentially the same idea. It became increasingly difficult to see the forest through the trees."
> That is SUCH a brilliant explanation of the worsening of obsessive-compulsiveness caused by stimulants. i've been trying to think how to describe that for awhile now and that's great-- "hyper-focusing" or i.e. "fixating", and the "forest through the trees" analogy. What's good for ADD is freaking TERRIBLE for OCD! (And what a b**ch it is to have both.) It IS counterproductive, ISn't it?!! i hATe it! It's like yeah i'll be able to focus better but how the !@#*^%$# do i UNfocus, or contROL the freaking focus???!
> Anyway, sorry, just wanted to get that out. A prior love relationship with stimulants has become a more aware hatred for those cursed, cursed, cursed drugs. (ok well they can be helpful soemtimes, but yeah). Oh and i still love my little caffeine-- oh lovely lovely blessed caffeine.
> P.S. And the fact that we are drugging millions of freaking kids on this crap (forced drugging, essentially-- oftentimes) infuriates me. Turning them into grandiose little obsessive-compulsive speed freaks before they even have a chance to realize whats going on or express it adequately or develop into maturity-- yeah that's wonderful. And no this didnt happen to me-- all my stimulant use was willful (and not nearly as much or often as many of these kids have to take), but i did so in ignorance. End shpiel.
poster:Caleb462
thread:234054
URL: http://www.dr-bob.org/babble/20030614/msgs/234328.html