Posted by cybercafe on June 11, 2003, at 2:27:09
In reply to Re: Ritch -- SSRIs » cybercafe, posted by Ritch on June 9, 2003, at 21:41:52
> SSRI's have a *very* flat dose-response curve. The only posts I've seen where additional SSRI dosage seems to yield considerable benefit is if OCD is involved. From personal experience with
hmm... that is interesting... though i know i felt better on 40 mg paxil than 20 mg and 225 mg effexor than 150 mg (assuming it acts as an SSRI in this range) ... i think i am feeling better on celexa, it's strange... effexor made me feel worse + effected sleeping habits when i first went on it... celexa has NO noticeable effects of a doseage increase... and for the first time since being depressed my libido is back
>Celexa.... I started off with 10mg and felt a LOT better (during the start of a major depressive episode where it would be warranted), but as it deepened I complained that my depression was starting to come back... we increased the dose to 20mg. All that happened was more side effects with little additional benefit. The bottom line with my major depressive spells is that a purely serotonergic agent doesn't cut it. IOW, it really didn't matter whether I took Celexa at 5mg, 10mg, or 20mg, the effect wasn't much different. Buspar introduced a NE/DA effect that signficantly helped-that may be why Effexor "worked" for you.
hey that's cool, i thought buspar was just a post synaptic 5ht1a agonist or something...
ummm... i took effexor at a purely ssri range... more norepenephrine means more cycling right?
>I've found that my bipolar depressions DON'T respond to serotonin agents exclusively, I have to bump the other neurotransmitters to get any relief.
hmmmm! ... yeah ... this ritalin is really great... i just started a pseudo job so we'll see how things work out.... but i hope to be rich and lavish my bipolar friends with gifts of aripiprazole in the near future :)
poster:cybercafe
thread:232337
URL: http://www.dr-bob.org/babble/20030609/msgs/233104.html