Re: Why Dirty Drug

Posted by stjames on May 4, 2003, at 1:46:44

In reply to Re: Why Dirty Drug, posted by SLS on May 1, 2003, at 8:51:19

> Hi Jack.
>
> > Scott, or others, why are TCA's and MAOI's referred to as dirty drugs? I have never quite understood this. Is it just because they are not selective.
Selective never seemed to work as hoped, given that the SSRI's have proven not as effective for more serious depressions. Poly-pharm makes drugs more "dirty" and tends to make the treatment more effective. This tends to disprove a number of neurotransmitter models for depression, also.
Dirty is also relative, as one persons unwanted side effects are anothers wanted effects. The only time in 30 years my allergies were mostly under control was the 5 or so years I was on TCA's.
Let's hear it for dirty drugs !

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