Posted by Caleb462 on May 1, 2003, at 23:04:38
In reply to Re: Why Effexor? » Ricardo, posted by ace on May 1, 2003, at 22:02:30
> That's simple: It is market immensly, everyone thinks newer=better, which is NOT true. TCAs, in many clinical, double blind placebo controlled studies, have been shown superior, sometimes greatly, to SSRI and drugs like Effexor. In addition, sure, sometimes it would be good for someone. Every serious doctor knows MAOI drugs to be very potent AD's. And, in addition, they have very little in terms of withdrawal. Recently I read Nardil (MAOI) has a w/drawal rate of 32%, and Paxil up in th high 70's%. If you w/drawal very slow with MAOIs and TCAs, very rarely will you have a problem. Not so with the newer AD's.
My theory on why TCAs are often more superior... because the anti-histaminic and anti-chollinergic effects contribute to the anti-depressant effect! Blocking of the H1 histamine receptor, for instance, has been shown to induce dopamine release.
poster:Caleb462
thread:223740
URL: http://www.dr-bob.org/babble/20030429/msgs/223765.html