Posted by djmmm on April 21, 2003, at 20:25:42
In reply to That research is old news., posted by linkadge on April 21, 2003, at 19:19:41
> MDMA does indeed damage the brain.
> Unlike reputake inhibitors, MDMA
> (the Amphetamine Derivitive of Mescalin)
> displaces Serotonin and Dopamine
> from the axon terminal. In experiments
> with high enough doses the serotonin
> synapses apear to corkscrew and die.
>
> They've known this since the 80's
>
I think MDMA is an Phenethylamine-empathogen, a substituted amphetamine, and has no hallucinogenic properties, the related compound MDA is somewhat hallucinogenicfood for thought..MDMA injected directly into the bran attenuates, and often causes no neurotoxicity..
the corkscrew shaped neurons are caused by the degredation of Dopamine with in serotonin axon terminals...serotonin neurons will take in dopamine is serotonin is not available.
>
> May I suggest reading "Drugs and the Brain"
> by Solomon H. Snyder.
>
> In this book it describes a process wherin
> dopamine and serotonin supplies are excausted
> producing a low grade crash the next day.
> If the dose is repeated to prevent this
> crash the next day, the high will be lower
> and the dammage will be greater.
>true for some, however I believe Alexander Shulgin, who brought this antiquated molecule back, found that on the 4th day of consecutive use, the effects were similar to amphetamine.
> You have to remember that the termnials maintain their integrity by holding adequate levels of the neurotrasmitters. If the chemical that displaces Serotonin (in this case MDMA) does not share the same protective properties as serotonin itself (which MDMA does not) then dammage is likely to follow.
this brings to mind fenfloramine, and the years of research showing the same damage as MDMA...yet the FDA decides to weigh the Pro's and con's, and allow it to be used daily for extendedd periods of time....
>
> Why do you think people started this whole
> prozac Neuroprotection system?
>
> http://www.mdma.net/protect/prozac.html
>
>
>
> The only reason that this dammage has not
> been seen in humans..Is because they have
> to cut the brain open to see it.and MDMA users are typically Poly-drug users
>
>
> Lets face it
> If they could accurately test the toxisity
> of psychoative drugs on humans then they
> would not use rats in the first place.true, but we must take into account, the dose/weight ratio...and on the pro-neurotoxic side, adulterants (DXM MPTP, etc)
>
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> Linkadge
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poster:djmmm
thread:220662
URL: http://www.dr-bob.org/babble/20030417/msgs/221278.html